Promethaine
Category
Promethaine Brand names, Promethaine Analogs
Promethaine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promethaine Chemical_Formula
C17H20N2S
Promethaine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promethaine fda sheet
Promethaine msds (material safety sheet)
Promethaine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promethaine Molecular Weight
284.42 g/mol
Promethaine Melting Point
60oC
Promethaine H2O Solubility
Freely soluble
Promethaine State
Solid
Promethaine LogP
4.946
Promethaine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promethaine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethaine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promethaine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promethaine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promethaine Patient Information
Promethaine Organisms Affected
Humans and other mammals
