Prometazin
Category
Prometazin Brand names, Prometazin Analogs
Prometazin Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Prometazin Chemical_Formula
C17H20N2S
Prometazin RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Prometazin fda sheet
Prometazin msds (material safety sheet)
Prometazin Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Prometazin Molecular Weight
284.42 g/mol
Prometazin Melting Point
60oC
Prometazin H2O Solubility
Freely soluble
Prometazin State
Solid
Prometazin LogP
4.946
Prometazin Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Prometazin Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Prometazin Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Prometazin Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Prometazin side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Prometazin Patient Information
Prometazin Organisms Affected
Humans and other mammals
