Promethegan
Category
Promethegan Brand names, Promethegan Analogs
Promethegan Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promethegan Chemical_Formula
C17H20N2S
Promethegan RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promethegan fda sheet
Promethegan msds (material safety sheet)
Promethegan Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promethegan Molecular Weight
284.42 g/mol
Promethegan Melting Point
60oC
Promethegan H2O Solubility
Freely soluble
Promethegan State
Solid
Promethegan LogP
4.946
Promethegan Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promethegan Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promethegan Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promethegan Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promethegan side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promethegan Patient Information
Promethegan Organisms Affected
Humans and other mammals
