Novo-Difenac SR
Brand names,
Novo-Difenac SR
Analogs
Novo-Difenac SR
Brand Names Mixture
Novo-Difenac SR
Chemical_Formula
C14H11Cl2NO2
Novo-Difenac SR
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Novo-Difenac SR
fda sheet
Novo-Difenac SR
msds (material safety sheet)
Novo-Difenac SR
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Novo-Difenac SR
Molecular Weight
296.148 g/mol
Novo-Difenac SR
Melting Point
283-285oC
Novo-Difenac SR
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Novo-Difenac SR
State
solid
Novo-Difenac SR
LogP
4.218
Novo-Difenac SR
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Novo-Difenac SR
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Novo-Difenac SR
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Novo-Difenac SR
Absorption
Completely absorbed from the gastrointestinal tract.
Novo-Difenac SR
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Novo-Difenac SR
Patient Information
Novo-Difenac SR
Organisms Affected
Humans and other mammals