Diclofenac Potassium
Brand names,
Diclofenac Potassium
Analogs
Diclofenac Potassium
Brand Names Mixture
Diclofenac Potassium
Chemical_Formula
C14H11Cl2NO2
Diclofenac Potassium
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Diclofenac Potassium
fda sheet
Diclofenac Potassium
msds (material safety sheet)
Diclofenac Potassium
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Diclofenac Potassium
Molecular Weight
296.148 g/mol
Diclofenac Potassium
Melting Point
283-285oC
Diclofenac Potassium
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Diclofenac Potassium
State
solid
Diclofenac Potassium
LogP
4.218
Diclofenac Potassium
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Diclofenac Potassium
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diclofenac Potassium
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Diclofenac Potassium
Absorption
Completely absorbed from the gastrointestinal tract.
Diclofenac Potassium
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Diclofenac Potassium
Patient Information
Diclofenac Potassium
Organisms Affected
Humans and other mammals