Diclofenac Sodium
Brand names,
Diclofenac Sodium
Analogs
Diclofenac Sodium
Brand Names Mixture
Diclofenac Sodium
Chemical_Formula
C14H11Cl2NO2
Diclofenac Sodium
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Diclofenac Sodium
fda sheet
Diclofenac Sodium
msds (material safety sheet)
Diclofenac Sodium
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Diclofenac Sodium
Molecular Weight
296.148 g/mol
Diclofenac Sodium
Melting Point
283-285oC
Diclofenac Sodium
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Diclofenac Sodium
State
solid
Diclofenac Sodium
LogP
4.218
Diclofenac Sodium
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Diclofenac Sodium
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diclofenac Sodium
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Diclofenac Sodium
Absorption
Completely absorbed from the gastrointestinal tract.
Diclofenac Sodium
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Diclofenac Sodium
Patient Information
Diclofenac Sodium
Organisms Affected
Humans and other mammals