Voldal
Brand names,
Voldal
Analogs
Voldal
Brand Names Mixture
Voldal
Chemical_Formula
C14H11Cl2NO2
Voldal
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Voldal
fda sheet
Voldal
msds (material safety sheet)
Voldal
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Voldal
Molecular Weight
296.148 g/mol
Voldal
Melting Point
283-285oC
Voldal
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Voldal
State
solid
Voldal
LogP
4.218
Voldal
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Voldal
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Voldal
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Voldal
Absorption
Completely absorbed from the gastrointestinal tract.
Voldal
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Voldal
Patient Information
Voldal
Organisms Affected
Humans and other mammals