Dichlofenac
Brand names,
Dichlofenac
Analogs
Dichlofenac
Brand Names Mixture
Dichlofenac
Chemical_Formula
C14H11Cl2NO2
Dichlofenac
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Dichlofenac
fda sheet
Dichlofenac
msds (material safety sheet)
Dichlofenac
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Dichlofenac
Molecular Weight
296.148 g/mol
Dichlofenac
Melting Point
283-285oC
Dichlofenac
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Dichlofenac
State
solid
Dichlofenac
LogP
4.218
Dichlofenac
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Dichlofenac
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Dichlofenac
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Dichlofenac
Absorption
Completely absorbed from the gastrointestinal tract.
Dichlofenac
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Dichlofenac
Patient Information
Dichlofenac
Organisms Affected
Humans and other mammals