Diclofenac Acid
Brand names,
Diclofenac Acid
Analogs
Diclofenac Acid
Brand Names Mixture
Diclofenac Acid
Chemical_Formula
C14H11Cl2NO2
Diclofenac Acid
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Diclofenac Acid
fda sheet
Diclofenac Acid
msds (material safety sheet)
Diclofenac Acid
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Diclofenac Acid
Molecular Weight
296.148 g/mol
Diclofenac Acid
Melting Point
283-285oC
Diclofenac Acid
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Diclofenac Acid
State
solid
Diclofenac Acid
LogP
4.218
Diclofenac Acid
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Diclofenac Acid
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diclofenac Acid
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Diclofenac Acid
Absorption
Completely absorbed from the gastrointestinal tract.
Diclofenac Acid
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Diclofenac Acid
Patient Information
Diclofenac Acid
Organisms Affected
Humans and other mammals