Diclobenin
Brand names,
Diclobenin
Analogs
Diclobenin
Brand Names Mixture
Diclobenin
Chemical_Formula
C14H11Cl2NO2
Diclobenin
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Diclobenin
fda sheet
Diclobenin
msds (material safety sheet)
Diclobenin
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Diclobenin
Molecular Weight
296.148 g/mol
Diclobenin
Melting Point
283-285oC
Diclobenin
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Diclobenin
State
solid
Diclobenin
LogP
4.218
Diclobenin
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Diclobenin
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diclobenin
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Diclobenin
Absorption
Completely absorbed from the gastrointestinal tract.
Diclobenin
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Diclobenin
Patient Information
Diclobenin
Organisms Affected
Humans and other mammals