Novo-Difenac
Brand names,
Novo-Difenac
Analogs
Novo-Difenac
Brand Names Mixture
Novo-Difenac
Chemical_Formula
C14H11Cl2NO2
Novo-Difenac
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Novo-Difenac
fda sheet
Novo-Difenac
msds (material safety sheet)
Novo-Difenac
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Novo-Difenac
Molecular Weight
296.148 g/mol
Novo-Difenac
Melting Point
283-285oC
Novo-Difenac
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Novo-Difenac
State
solid
Novo-Difenac
LogP
4.218
Novo-Difenac
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Novo-Difenac
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Novo-Difenac
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Novo-Difenac
Absorption
Completely absorbed from the gastrointestinal tract.
Novo-Difenac
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Novo-Difenac
Patient Information
Novo-Difenac
Organisms Affected
Humans and other mammals