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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C14H11Cl2NO2
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RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
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Molecular Weight
296.148 g/mol
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Melting Point
283-285oC
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H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
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State
solid
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LogP
4.218
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Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
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Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
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Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
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Absorption
Completely absorbed from the gastrointestinal tract.
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side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
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Patient Information
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Organisms Affected
Humans and other mammals