Kriplex
Brand names,
Kriplex
Analogs
Kriplex
Brand Names Mixture
Kriplex
Chemical_Formula
C14H11Cl2NO2
Kriplex
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Kriplex
fda sheet
Kriplex
msds (material safety sheet)
Kriplex
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Kriplex
Molecular Weight
296.148 g/mol
Kriplex
Melting Point
283-285oC
Kriplex
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Kriplex
State
solid
Kriplex
LogP
4.218
Kriplex
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Kriplex
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Kriplex
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Kriplex
Absorption
Completely absorbed from the gastrointestinal tract.
Kriplex
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Kriplex
Patient Information
Kriplex
Organisms Affected
Humans and other mammals