Primofenac
Brand names,
Primofenac
Analogs
Primofenac
Brand Names Mixture
Primofenac
Chemical_Formula
C14H11Cl2NO2
Primofenac
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Primofenac
fda sheet
Primofenac
msds (material safety sheet)
Primofenac
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Primofenac
Molecular Weight
296.148 g/mol
Primofenac
Melting Point
283-285oC
Primofenac
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Primofenac
State
solid
Primofenac
LogP
4.218
Primofenac
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Primofenac
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Primofenac
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Primofenac
Absorption
Completely absorbed from the gastrointestinal tract.
Primofenac
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Primofenac
Patient Information
Primofenac
Organisms Affected
Humans and other mammals