Pennsaid
Brand names,
Pennsaid
Analogs
Pennsaid
Brand Names Mixture
Pennsaid
Chemical_Formula
C14H11Cl2NO2
Pennsaid
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Pennsaid
fda sheet
Pennsaid
msds (material safety sheet)
Pennsaid
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Pennsaid
Molecular Weight
296.148 g/mol
Pennsaid
Melting Point
283-285oC
Pennsaid
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Pennsaid
State
solid
Pennsaid
LogP
4.218
Pennsaid
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Pennsaid
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Pennsaid
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Pennsaid
Absorption
Completely absorbed from the gastrointestinal tract.
Pennsaid
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Pennsaid
Patient Information
Pennsaid
Organisms Affected
Humans and other mammals