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Midefam Brand names, Midefam Analogs

Midefam Brand Names Mixture

  • No information avaliable

Midefam Chemical_Formula


Midefam RX_link


Midefam fda sheet

Midefam FDA

Midefam msds (material safety sheet)

Midefam MSDS

Midefam Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Midefam Molecular Weight

337.449 g/mol

Midefam Melting Point

163-164 oC

Midefam H2O Solubility

1.1 mg/mL

Midefam State


Midefam LogP


Midefam Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Midefam Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Midefam Pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Midefam Absorption

The bioavailability of oral doses is 40-45%.

Midefam side effects and Toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Midefam Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Midefam Organisms Affected

Humans and other mammals