Confobos

Confobos Brand names, Confobos Analogs

Confobos Brand Names Mixture

No information avaliable

Confobos Chemical_Formula

C₈H₁₅N₇O₂S₃

Confobos RX_link

http://www.rxlist.com/cgi/generic/famot.htm

Confobos fda sheet

Confobos FDA

Confobos msds (material safety sheet)

Confobos MSDS

Confobos Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Confobos Molecular Weight

337.449 g/mol

Confobos Melting Point

163-164 ^oC

Confobos H₂O Solubility

1.1 mg/mL

Confobos State

Solid

Confobos LogP

-0.726

Confobos Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Confobos Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Confobos Pharmacology

Famotidine, a competitive histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Confobos Absorption

The bioavailability of oral doses is 40-45%.

Confobos side effects and Toxicity

Intravenous, mouse: LD₅₀ = 244.4mg/kg; Oral, mouse: LD₅₀ = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Confobos Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Confobos Organisms Affected

Humans and other mammals