Famotidinum [Latin]

Famotidinum [Latin] Brand names, Famotidinum [Latin] Analogs

Famotidinum [Latin] Brand Names Mixture

No information avaliable

Famotidinum [Latin] Chemical_Formula

C₈H₁₅N₇O₂S₃

Famotidinum [Latin] RX_link

http://www.rxlist.com/cgi/generic/famot.htm

Famotidinum [Latin] fda sheet

Famotidinum_[Latin] FDA

Famotidinum [Latin] msds (material safety sheet)

Famotidinum_[Latin] MSDS

Famotidinum [Latin] Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Famotidinum [Latin] Molecular Weight

337.449 g/mol

Famotidinum [Latin] Melting Point

163-164 ^oC

Famotidinum [Latin] H₂O Solubility

1.1 mg/mL

Famotidinum [Latin] State

Solid

Famotidinum [Latin] LogP

-0.726

Famotidinum [Latin] Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Famotidinum [Latin] Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Famotidinum [Latin] Pharmacology

Famotidine, a competitive histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Famotidinum [Latin] Absorption

The bioavailability of oral doses is 40-45%.

Famotidinum [Latin] side effects and Toxicity

Intravenous, mouse: LD₅₀ = 244.4mg/kg; Oral, mouse: LD₅₀ = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Famotidinum [Latin] Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Famotidinum [Latin] Organisms Affected

Humans and other mammals