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Apogastine Brand names, Apogastine Analogs

Apogastine Brand Names Mixture

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Apogastine Chemical_Formula


Apogastine RX_link


Apogastine fda sheet

Apogastine FDA

Apogastine msds (material safety sheet)

Apogastine MSDS

Apogastine Synthesis Reference

H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)

Apogastine Molecular Weight

337.449 g/mol

Apogastine Melting Point

163-164 oC

Apogastine H2O Solubility

1.1 mg/mL

Apogastine State


Apogastine LogP


Apogastine Dosage Forms

Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution

Apogastine Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Apogastine Pharmacology

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Apogastine Absorption

The bioavailability of oral doses is 40-45%.

Apogastine side effects and Toxicity

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Apogastine Patient Information

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Apogastine Organisms Affected

Humans and other mammals