Fanosin
Brand names,
Fanosin
Analogs
Fanosin
Brand Names Mixture
Fanosin
Chemical_Formula
C8H15N7O2S3
Fanosin
RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Fanosin
fda sheet
Fanosin
msds (material safety sheet)
Fanosin
Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Fanosin
Molecular Weight
337.449 g/mol
Fanosin
Melting Point
163-164 oC
Fanosin
H2O Solubility
1.1 mg/mL
Fanosin
State
Solid
Fanosin
LogP
-0.726
Fanosin
Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Fanosin
Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Fanosin
Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Fanosin
Absorption
The bioavailability of oral doses is 40-45%.
Fanosin
side effects and Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Fanosin
Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Fanosin
Organisms Affected
Humans and other mammals