Famotep
Brand names,
Famotep
Analogs
Famotep
Brand Names Mixture
Famotep
Chemical_Formula
C8H15N7O2S3
Famotep
RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Famotep
fda sheet
Famotep
msds (material safety sheet)
Famotep
Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Famotep
Molecular Weight
337.449 g/mol
Famotep
Melting Point
163-164 oC
Famotep
H2O Solubility
1.1 mg/mL
Famotep
State
Solid
Famotep
LogP
-0.726
Famotep
Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Famotep
Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Famotep
Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Famotep
Absorption
The bioavailability of oral doses is 40-45%.
Famotep
side effects and Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Famotep
Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Famotep
Organisms Affected
Humans and other mammals