Famowal
Brand names,
Famowal
Analogs
Famowal
Brand Names Mixture
Famowal
Chemical_Formula
C8H15N7O2S3
Famowal
RX_link
http://www.rxlist.com/cgi/generic/famot.htm
Famowal
fda sheet
Famowal
msds (material safety sheet)
Famowal
Synthesis Reference
H. Yasufumi et al.; U.S. Pat. 4,283,408 (1981)
Famowal
Molecular Weight
337.449 g/mol
Famowal
Melting Point
163-164 oC
Famowal
H2O Solubility
1.1 mg/mL
Famowal
State
Solid
Famowal
LogP
-0.726
Famowal
Dosage Forms
Oral tablets; Rapid disintergrating tablets; Suspension; Injectable solution
Famowal
Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Famowal
Pharmacology
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Famowal
Absorption
The bioavailability of oral doses is 40-45%.
Famowal
side effects and Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Famowal
Patient Information
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.
Famowal
Organisms Affected
Humans and other mammals