Diclofenac
Brand names,
Diclofenac
Analogs
Diclofenac
Brand Names Mixture
Diclofenac
Chemical_Formula
C14H11Cl2NO2
Diclofenac
RX_link
http://www.rxlist.com/cgi/generic/diclofen.htm
Diclofenac
fda sheet
Diclofenac
msds (material safety sheet)
Diclofenac
Synthesis Reference
A. Sallman, R. Pfister, U.S. Pat. 3,558,690, (1971)
Diclofenac
Molecular Weight
296.148 g/mol
Diclofenac
Melting Point
283-285oC
Diclofenac
H2O Solubility
0.00082 mg/mL (Na salt); 2.43 mg/mL (K salt)
Diclofenac
State
solid
Diclofenac
LogP
4.218
Diclofenac
Dosage Forms
Tablet (extended-release); Tablet (immediate-release)
Diclofenac
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Diclofenac
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Diclofenac
Absorption
Completely absorbed from the gastrointestinal tract.
Diclofenac
side effects and Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Diclofenac
Patient Information
Diclofenac
Organisms Affected
Humans and other mammals