beta-BHC
Category
beta-BHC Brand names, beta-BHC Analogs
beta-BHC Brand Names Mixture
beta-BHC Chemical_Formula
C24H31ClO7
beta-BHC RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
beta-BHC fda sheet
beta-BHC msds (material safety sheet)
beta-BHC Synthesis Reference
No information avaliable
beta-BHC Molecular Weight
466.951 g/mol
beta-BHC Melting Point
220-224 oC
beta-BHC H2O Solubility
5 mg/mL
beta-BHC State
Solid
beta-BHC LogP
4.004
beta-BHC Dosage Forms
Solution; Spray
beta-BHC Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
beta-BHC Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
beta-BHC Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
beta-BHC side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
beta-BHC Patient Information
beta-BHC Organisms Affected
Humans and other mammals
