Gammalin
Category
Gammalin Brand names, Gammalin Analogs
Gammalin Brand Names Mixture
Gammalin Chemical_Formula
C24H31ClO7
Gammalin RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammalin fda sheet
Gammalin msds (material safety sheet)
Gammalin Synthesis Reference
No information avaliable
Gammalin Molecular Weight
466.951 g/mol
Gammalin Melting Point
220-224 oC
Gammalin H2O Solubility
5 mg/mL
Gammalin State
Solid
Gammalin LogP
4.004
Gammalin Dosage Forms
Solution; Spray
Gammalin Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammalin Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammalin Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammalin side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammalin Patient Information
Gammalin Organisms Affected
Humans and other mammals
