Gammaterr
Category
Gammaterr Brand names, Gammaterr Analogs
Gammaterr Brand Names Mixture
Gammaterr Chemical_Formula
C24H31ClO7
Gammaterr RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammaterr fda sheet
Gammaterr msds (material safety sheet)
Gammaterr Synthesis Reference
No information avaliable
Gammaterr Molecular Weight
466.951 g/mol
Gammaterr Melting Point
220-224 oC
Gammaterr H2O Solubility
5 mg/mL
Gammaterr State
Solid
Gammaterr LogP
4.004
Gammaterr Dosage Forms
Solution; Spray
Gammaterr Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammaterr Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammaterr Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammaterr side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammaterr Patient Information
Gammaterr Organisms Affected
Humans and other mammals
