Nexit-Stark
Category
Nexit-Stark Brand names, Nexit-Stark Analogs
Nexit-Stark Brand Names Mixture
Nexit-Stark Chemical_Formula
C24H31ClO7
Nexit-Stark RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Nexit-Stark fda sheet
Nexit-Stark msds (material safety sheet)
Nexit-Stark Synthesis Reference
No information avaliable
Nexit-Stark Molecular Weight
466.951 g/mol
Nexit-Stark Melting Point
220-224 oC
Nexit-Stark H2O Solubility
5 mg/mL
Nexit-Stark State
Solid
Nexit-Stark LogP
4.004
Nexit-Stark Dosage Forms
Solution; Spray
Nexit-Stark Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Nexit-Stark Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Nexit-Stark Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Nexit-Stark side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Nexit-Stark Patient Information
Nexit-Stark Organisms Affected
Humans and other mammals
