Gamene
Category
Gamene Brand names, Gamene Analogs
Gamene Brand Names Mixture
Gamene Chemical_Formula
C24H31ClO7
Gamene RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gamene fda sheet
Gamene msds (material safety sheet)
Gamene Synthesis Reference
No information avaliable
Gamene Molecular Weight
466.951 g/mol
Gamene Melting Point
220-224 oC
Gamene H2O Solubility
5 mg/mL
Gamene State
Solid
Gamene LogP
4.004
Gamene Dosage Forms
Solution; Spray
Gamene Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gamene Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gamene Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gamene side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gamene Patient Information
Gamene Organisms Affected
Humans and other mammals
