Hexachlorocyclohexane
Category
Hexachlorocyclohexane Brand names, Hexachlorocyclohexane Analogs
Hexachlorocyclohexane Brand Names Mixture
Hexachlorocyclohexane Chemical_Formula
C24H31ClO7
Hexachlorocyclohexane RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexachlorocyclohexane fda sheet
Hexachlorocyclohexane msds (material safety sheet)
Hexachlorocyclohexane Synthesis Reference
No information avaliable
Hexachlorocyclohexane Molecular Weight
466.951 g/mol
Hexachlorocyclohexane Melting Point
220-224 oC
Hexachlorocyclohexane H2O Solubility
5 mg/mL
Hexachlorocyclohexane State
Solid
Hexachlorocyclohexane LogP
4.004
Hexachlorocyclohexane Dosage Forms
Solution; Spray
Hexachlorocyclohexane Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexachlorocyclohexane Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexachlorocyclohexane Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexachlorocyclohexane side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexachlorocyclohexane Patient Information
Hexachlorocyclohexane Organisms Affected
Humans and other mammals
