Ovadziak
Category
Ovadziak Brand names, Ovadziak Analogs
Ovadziak Brand Names Mixture
Ovadziak Chemical_Formula
C24H31ClO7
Ovadziak RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Ovadziak fda sheet
Ovadziak msds (material safety sheet)
Ovadziak Synthesis Reference
No information avaliable
Ovadziak Molecular Weight
466.951 g/mol
Ovadziak Melting Point
220-224 oC
Ovadziak H2O Solubility
5 mg/mL
Ovadziak State
Solid
Ovadziak LogP
4.004
Ovadziak Dosage Forms
Solution; Spray
Ovadziak Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Ovadziak Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Ovadziak Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Ovadziak side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Ovadziak Patient Information
Ovadziak Organisms Affected
Humans and other mammals
