Lentox
Category
Lentox Brand names, Lentox Analogs
Lentox Brand Names Mixture
Lentox Chemical_Formula
C24H31ClO7
Lentox RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lentox fda sheet
Lentox msds (material safety sheet)
Lentox Synthesis Reference
No information avaliable
Lentox Molecular Weight
466.951 g/mol
Lentox Melting Point
220-224 oC
Lentox H2O Solubility
5 mg/mL
Lentox State
Solid
Lentox LogP
4.004
Lentox Dosage Forms
Solution; Spray
Lentox Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lentox Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lentox Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lentox side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lentox Patient Information
Lentox Organisms Affected
Humans and other mammals
