Gammexane
Category
Gammexane Brand names, Gammexane Analogs
Gammexane Brand Names Mixture
Gammexane Chemical_Formula
C24H31ClO7
Gammexane RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammexane fda sheet
Gammexane msds (material safety sheet)
Gammexane Synthesis Reference
No information avaliable
Gammexane Molecular Weight
466.951 g/mol
Gammexane Melting Point
220-224 oC
Gammexane H2O Solubility
5 mg/mL
Gammexane State
Solid
Gammexane LogP
4.004
Gammexane Dosage Forms
Solution; Spray
Gammexane Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammexane Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammexane Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammexane side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammexane Patient Information
Gammexane Organisms Affected
Humans and other mammals
