Hortex
Category
Hortex Brand names, Hortex Analogs
Hortex Brand Names Mixture
Hortex Chemical_Formula
C24H31ClO7
Hortex RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hortex fda sheet
Hortex msds (material safety sheet)
Hortex Synthesis Reference
No information avaliable
Hortex Molecular Weight
466.951 g/mol
Hortex Melting Point
220-224 oC
Hortex H2O Solubility
5 mg/mL
Hortex State
Solid
Hortex LogP
4.004
Hortex Dosage Forms
Solution; Spray
Hortex Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hortex Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hortex Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hortex side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hortex Patient Information
Hortex Organisms Affected
Humans and other mammals
