Chloresene
Category
Chloresene Brand names, Chloresene Analogs
Chloresene Brand Names Mixture
Chloresene Chemical_Formula
C24H31ClO7
Chloresene RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Chloresene fda sheet
Chloresene msds (material safety sheet)
Chloresene Synthesis Reference
No information avaliable
Chloresene Molecular Weight
466.951 g/mol
Chloresene Melting Point
220-224 oC
Chloresene H2O Solubility
5 mg/mL
Chloresene State
Solid
Chloresene LogP
4.004
Chloresene Dosage Forms
Solution; Spray
Chloresene Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Chloresene Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Chloresene Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Chloresene side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Chloresene Patient Information
Chloresene Organisms Affected
Humans and other mammals
