Codechine
Category
Codechine Brand names, Codechine Analogs
Codechine Brand Names Mixture
Codechine Chemical_Formula
C24H31ClO7
Codechine RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Codechine fda sheet
Codechine msds (material safety sheet)
Codechine Synthesis Reference
No information avaliable
Codechine Molecular Weight
466.951 g/mol
Codechine Melting Point
220-224 oC
Codechine H2O Solubility
5 mg/mL
Codechine State
Solid
Codechine LogP
4.004
Codechine Dosage Forms
Solution; Spray
Codechine Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Codechine Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Codechine Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Codechine side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Codechine Patient Information
Codechine Organisms Affected
Humans and other mammals
