Ben-Hex
Category
Ben-Hex Brand names, Ben-Hex Analogs
Ben-Hex Brand Names Mixture
Ben-Hex Chemical_Formula
C24H31ClO7
Ben-Hex RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Ben-Hex fda sheet
Ben-Hex msds (material safety sheet)
Ben-Hex Synthesis Reference
No information avaliable
Ben-Hex Molecular Weight
466.951 g/mol
Ben-Hex Melting Point
220-224 oC
Ben-Hex H2O Solubility
5 mg/mL
Ben-Hex State
Solid
Ben-Hex LogP
4.004
Ben-Hex Dosage Forms
Solution; Spray
Ben-Hex Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Ben-Hex Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Ben-Hex Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Ben-Hex side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Ben-Hex Patient Information
Ben-Hex Organisms Affected
Humans and other mammals
