Jacutin
Category
Jacutin Brand names, Jacutin Analogs
Jacutin Brand Names Mixture
Jacutin Chemical_Formula
C24H31ClO7
Jacutin RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Jacutin fda sheet
Jacutin msds (material safety sheet)
Jacutin Synthesis Reference
No information avaliable
Jacutin Molecular Weight
466.951 g/mol
Jacutin Melting Point
220-224 oC
Jacutin H2O Solubility
5 mg/mL
Jacutin State
Solid
Jacutin LogP
4.004
Jacutin Dosage Forms
Solution; Spray
Jacutin Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Jacutin Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Jacutin Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Jacutin side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Jacutin Patient Information
Jacutin Organisms Affected
Humans and other mammals
