Scabene
Category
Scabene Brand names, Scabene Analogs
Scabene Brand Names Mixture
Scabene Chemical_Formula
C24H31ClO7
Scabene RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Scabene fda sheet
Scabene msds (material safety sheet)
Scabene Synthesis Reference
No information avaliable
Scabene Molecular Weight
466.951 g/mol
Scabene Melting Point
220-224 oC
Scabene H2O Solubility
5 mg/mL
Scabene State
Solid
Scabene LogP
4.004
Scabene Dosage Forms
Solution; Spray
Scabene Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Scabene Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Scabene Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Scabene side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Scabene Patient Information
Scabene Organisms Affected
Humans and other mammals
