Thacapzol
Thacapzol Brand names, Thacapzol Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Thacapzol Brand Names Mixture
- No information avaliable
Thacapzol Chemical_Formula
C4H6N2S
Thacapzol RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Thacapzol fda sheet
Thacapzol msds (material safety sheet)
Thacapzol Synthesis Reference
No information avaliable
Thacapzol Molecular Weight
114.17 g/mol
Thacapzol Melting Point
146 oC
Thacapzol H2O Solubility
275 g/L
Thacapzol State
Solid
Thacapzol LogP
-0.34
Thacapzol Dosage Forms
Tablet (5 or 10 mg)
Thacapzol Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Thacapzol Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Thacapzol Absorption
Rapid with an oral bioavailability of 93%.
Thacapzol side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Thacapzol Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Thacapzol Organisms Affected
Humans and other mammals
