Tapazole
Tapazole Brand names, Tapazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Tapazole Brand Names Mixture
- No information avaliable
Tapazole Chemical_Formula
C4H6N2S
Tapazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Tapazole fda sheet
Tapazole msds (material safety sheet)
Tapazole Synthesis Reference
No information avaliable
Tapazole Molecular Weight
114.17 g/mol
Tapazole Melting Point
146 oC
Tapazole H2O Solubility
275 g/L
Tapazole State
Solid
Tapazole LogP
-0.34
Tapazole Dosage Forms
Tablet (5 or 10 mg)
Tapazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Tapazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Tapazole Absorption
Rapid with an oral bioavailability of 93%.
Tapazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Tapazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Tapazole Organisms Affected
Humans and other mammals
