Methimazol
Methimazol Brand names, Methimazol Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Methimazol Brand Names Mixture
- No information avaliable
Methimazol Chemical_Formula
C4H6N2S
Methimazol RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Methimazol fda sheet
Methimazol msds (material safety sheet)
Methimazol Synthesis Reference
No information avaliable
Methimazol Molecular Weight
114.17 g/mol
Methimazol Melting Point
146 oC
Methimazol H2O Solubility
275 g/L
Methimazol State
Solid
Methimazol LogP
-0.34
Methimazol Dosage Forms
Tablet (5 or 10 mg)
Methimazol Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Methimazol Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Methimazol Absorption
Rapid with an oral bioavailability of 93%.
Methimazol side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Methimazol Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Methimazol Organisms Affected
Humans and other mammals
