Thymidazole
Thymidazole Brand names, Thymidazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Thymidazole Brand Names Mixture
- No information avaliable
Thymidazole Chemical_Formula
C4H6N2S
Thymidazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Thymidazole fda sheet
Thymidazole msds (material safety sheet)
Thymidazole Synthesis Reference
No information avaliable
Thymidazole Molecular Weight
114.17 g/mol
Thymidazole Melting Point
146 oC
Thymidazole H2O Solubility
275 g/L
Thymidazole State
Solid
Thymidazole LogP
-0.34
Thymidazole Dosage Forms
Tablet (5 or 10 mg)
Thymidazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Thymidazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Thymidazole Absorption
Rapid with an oral bioavailability of 93%.
Thymidazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Thymidazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Thymidazole Organisms Affected
Humans and other mammals
