Metizol
Metizol Brand names, Metizol Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Metizol Brand Names Mixture
- No information avaliable
Metizol Chemical_Formula
C4H6N2S
Metizol RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Metizol fda sheet
Metizol msds (material safety sheet)
Metizol Synthesis Reference
No information avaliable
Metizol Molecular Weight
114.17 g/mol
Metizol Melting Point
146 oC
Metizol H2O Solubility
275 g/L
Metizol State
Solid
Metizol LogP
-0.34
Metizol Dosage Forms
Tablet (5 or 10 mg)
Metizol Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Metizol Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Metizol Absorption
Rapid with an oral bioavailability of 93%.
Metizol side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Metizol Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Metizol Organisms Affected
Humans and other mammals
