Thimazole
Thimazole Brand names, Thimazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Thimazole Brand Names Mixture
- No information avaliable
Thimazole Chemical_Formula
C4H6N2S
Thimazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Thimazole fda sheet
Thimazole msds (material safety sheet)
Thimazole Synthesis Reference
No information avaliable
Thimazole Molecular Weight
114.17 g/mol
Thimazole Melting Point
146 oC
Thimazole H2O Solubility
275 g/L
Thimazole State
Solid
Thimazole LogP
-0.34
Thimazole Dosage Forms
Tablet (5 or 10 mg)
Thimazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Thimazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Thimazole Absorption
Rapid with an oral bioavailability of 93%.
Thimazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Thimazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Thimazole Organisms Affected
Humans and other mammals
