Frentirox
Frentirox Brand names, Frentirox Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Frentirox Brand Names Mixture
- No information avaliable
Frentirox Chemical_Formula
C4H6N2S
Frentirox RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Frentirox fda sheet
Frentirox msds (material safety sheet)
Frentirox Synthesis Reference
No information avaliable
Frentirox Molecular Weight
114.17 g/mol
Frentirox Melting Point
146 oC
Frentirox H2O Solubility
275 g/L
Frentirox State
Solid
Frentirox LogP
-0.34
Frentirox Dosage Forms
Tablet (5 or 10 mg)
Frentirox Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Frentirox Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Frentirox Absorption
Rapid with an oral bioavailability of 93%.
Frentirox side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Frentirox Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Frentirox Organisms Affected
Humans and other mammals
