Metazolo
Metazolo Brand names, Metazolo Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Metazolo Brand Names Mixture
- No information avaliable
Metazolo Chemical_Formula
C4H6N2S
Metazolo RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Metazolo fda sheet
Metazolo msds (material safety sheet)
Metazolo Synthesis Reference
No information avaliable
Metazolo Molecular Weight
114.17 g/mol
Metazolo Melting Point
146 oC
Metazolo H2O Solubility
275 g/L
Metazolo State
Solid
Metazolo LogP
-0.34
Metazolo Dosage Forms
Tablet (5 or 10 mg)
Metazolo Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Metazolo Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Metazolo Absorption
Rapid with an oral bioavailability of 93%.
Metazolo side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Metazolo Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Metazolo Organisms Affected
Humans and other mammals
