Propyl-Thyracil
Propyl-Thyracil Brand names, Propyl-Thyracil Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Propyl-Thyracil Brand Names Mixture
- No information avaliable
Propyl-Thyracil Chemical_Formula
C4H6N2S
Propyl-Thyracil RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Propyl-Thyracil fda sheet
Propyl-Thyracil msds (material safety sheet)
Propyl-Thyracil Synthesis Reference
No information avaliable
Propyl-Thyracil Molecular Weight
114.17 g/mol
Propyl-Thyracil Melting Point
146 oC
Propyl-Thyracil H2O Solubility
275 g/L
Propyl-Thyracil State
Solid
Propyl-Thyracil LogP
-0.34
Propyl-Thyracil Dosage Forms
Tablet (5 or 10 mg)
Propyl-Thyracil Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Propyl-Thyracil Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Propyl-Thyracil Absorption
Rapid with an oral bioavailability of 93%.
Propyl-Thyracil side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Propyl-Thyracil Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Propyl-Thyracil Organisms Affected
Humans and other mammals
