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Metothyrine Brand names, Metothyrine Analogs

Metothyrine Brand Names Mixture

  • No information avaliable

Metothyrine Chemical_Formula


Metothyrine RX_link

Metothyrine fda sheet

Metothyrine msds (material safety sheet)

Metothyrine MSDS

Metothyrine Synthesis Reference

No information avaliable

Metothyrine Molecular Weight

114.17 g/mol

Metothyrine Melting Point

146 oC

Metothyrine H2O Solubility

275 g/L

Metothyrine State


Metothyrine LogP


Metothyrine Dosage Forms

Tablet (5 or 10 mg)

Metothyrine Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Metothyrine Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Metothyrine Absorption

Rapid with an oral bioavailability of 93%.

Metothyrine side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Metothyrine Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Metothyrine Organisms Affected

Humans and other mammals