Metothyrine
Metothyrine Brand names, Metothyrine Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Metothyrine Brand Names Mixture
- No information avaliable
Metothyrine Chemical_Formula
C4H6N2S
Metothyrine RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Metothyrine fda sheet
Metothyrine msds (material safety sheet)
Metothyrine Synthesis Reference
No information avaliable
Metothyrine Molecular Weight
114.17 g/mol
Metothyrine Melting Point
146 oC
Metothyrine H2O Solubility
275 g/L
Metothyrine State
Solid
Metothyrine LogP
-0.34
Metothyrine Dosage Forms
Tablet (5 or 10 mg)
Metothyrine Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Metothyrine Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Metothyrine Absorption
Rapid with an oral bioavailability of 93%.
Metothyrine side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Metothyrine Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Metothyrine Organisms Affected
Humans and other mammals
