Methiamazole
Methiamazole Brand names, Methiamazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Methiamazole Brand Names Mixture
- No information avaliable
Methiamazole Chemical_Formula
C4H6N2S
Methiamazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Methiamazole fda sheet
Methiamazole msds (material safety sheet)
Methiamazole Synthesis Reference
No information avaliable
Methiamazole Molecular Weight
114.17 g/mol
Methiamazole Melting Point
146 oC
Methiamazole H2O Solubility
275 g/L
Methiamazole State
Solid
Methiamazole LogP
-0.34
Methiamazole Dosage Forms
Tablet (5 or 10 mg)
Methiamazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Methiamazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Methiamazole Absorption
Rapid with an oral bioavailability of 93%.
Methiamazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Methiamazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Methiamazole Organisms Affected
Humans and other mammals
