Methiamazole en es it fr

Methiamazole Brand names, Methiamazole Analogs

Methiamazole Brand Names Mixture

  • No information avaliable

Methiamazole Chemical_Formula

C4H6N2S

Methiamazole RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Methiamazole fda sheet

Methiamazole msds (material safety sheet)

Methiamazole MSDS

Methiamazole Synthesis Reference

No information avaliable

Methiamazole Molecular Weight

114.17 g/mol

Methiamazole Melting Point

146 oC

Methiamazole H2O Solubility

275 g/L

Methiamazole State

Solid

Methiamazole LogP

-0.34

Methiamazole Dosage Forms

Tablet (5 or 10 mg)

Methiamazole Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Methiamazole Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Methiamazole Absorption

Rapid with an oral bioavailability of 93%.

Methiamazole side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Methiamazole Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Methiamazole Organisms Affected

Humans and other mammals