Methamazole
Methamazole Brand names, Methamazole Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Methamazole Brand Names Mixture
- No information avaliable
Methamazole Chemical_Formula
C4H6N2S
Methamazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Methamazole fda sheet
Methamazole msds (material safety sheet)
Methamazole Synthesis Reference
No information avaliable
Methamazole Molecular Weight
114.17 g/mol
Methamazole Melting Point
146 oC
Methamazole H2O Solubility
275 g/L
Methamazole State
Solid
Methamazole LogP
-0.34
Methamazole Dosage Forms
Tablet (5 or 10 mg)
Methamazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Methamazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Methamazole Absorption
Rapid with an oral bioavailability of 93%.
Methamazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Methamazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Methamazole Organisms Affected
Humans and other mammals
